Loading...
Trigonelline (NAD+ Precursor)
A unique NAD⁺ precursor that promotes muscle-specific NAD⁺ production and supports cognitive, cardiovascular, and metabolic health.
Free sample each month
Pause or cancel anytime
365 day free returns
Back in stock: 28/06/2025
Buy now, pay later from £11.87/mo with
Free UK shipping over £50, free returns.
Key Benefits
-
Promotes NAD⁺ production in muscle cells.
-
Supports brain health and cognitive function.
-
Enhances metabolic balance and cardiovascular health.
-
Acid-resistant capsules for optimal absorption.
Trigonelline (NAD⁺ Precursor) offers a unique way to restore NAD⁺ levels in the body, supporting energy production, muscle strength, and cognitive performance.
Unlike other NAD⁺ boosters such as NMN or NR, Trigonelline works through the Preiss-Handler pathway, directly elevating NAD⁺ levels in muscle tissues. This methylated form of niacin also crosses the blood-brain barrier, offering neuroprotective benefits and supporting cognitive resilience as you age. Trigonelline acts as a methyl donor in one-carbon metabolism, helping with energy production and genetic expression, and it promotes cardiovascular health by supporting endothelial function.
Research shows that Trigonelline remains stable in circulation for over 72 hours, offering a sustained impact compared to the shorter-lived NMN or NR. It also helps manage glucose and lipid metabolism, enhances insulin sensitivity, and supports muscle strength to maintain physical fitness over time.
To ensure proper uptake, Trigonelline is delivered in acid-resistant capsules that shield it from digestion and release it slowly in the gut, enhancing absorption across more tissues.
Trigonelline (NAD⁺ Precursor) stands out for its exceptional stability in the bloodstream, slow release into target tissues, and non-flushing effects, making it an ideal NAD⁺ booster for sensitive individuals. Encapsulated in acid-resistant capsules, Trigonelline is protected against digestion in the stomach, ensuring it reaches the small intestine intact for maximum uptake. With this delivery system, you’ll gain longer-lasting support for NAD⁺ production and overall health.
Bryan Nettles founded Renue by Science back in 2017, inspired by his passion for research and science regarding healthy ageing. In addition to fitness, diet, and sleep, supplements have played an essential role in his life. Bryan’s mission is to educate and motivate people to live long and strong lives. Today, Renue by Science offers the highest quality, most comprehensive range of bioavailable longevity products at the best possible price. They work with leading experts and doctors to stay updated on the latest research, using these insights and customer feedback to bring you the most effective solutions available.
With our Healf Curation Process, we do the work for you. Shop with confidence knowing that every item has been tried, tested, and curated for you.
Learn more about each step—Brand Discovery, Expert Validation, and Community Testing—here.
Shipping
At Healf, we prioritize safe and fast delivery for all our customers. Our carefully selected couriers are Royal Mail and DPD.
UK standard delivery
Enjoy free standard delivery on orders above £50, this option usually requires 2-3 working days. If your order is under £50, this delivery option is available for £3.99.
Next working day
For when you need our products urgently, we offer next working day shipping for £5.99. For orders placed before 12.00, we will ship it the same day to ensure you receive your order the next working day.
International
International deliveries can take 7 working days, and up to 4 weeks. The cost is £22.99 for orders below £50, £49.95 for orders above.
Returns
If for any reason you are not satisfied with your order, we provide free 365-day UK returns for all our customers. To initiate your return, simply contact us at team@healf.com, and we'll send you a return slip and help arrange a collection. The item you return must be sent in the same condition as received and inside the original packaging. Once received, we will notify you via email.
For international returns, we unfortunately do not cover the cost. However, we work with an array of carriers and can offer self-posting returns for customers shopping from outside the UK.
You may also like
Shop by collection
Frequently asked questions
Every product undergoes our Healf Curation Process. With it, you can shop confidently knowing that every item has been tried and tested before it reaches you. Our Healf Curation Process includes three key steps: Brand Discovery, Expert Validation, and Community Testing. Through these, we assess quality, ingredients, effectiveness, and more, ensuring that every product empowers your wellbeing.
The Healf Journal offers detailed insights into different aspects of wellbeing, as well as guidance, research, recipes, and more to help you invest in your personal wellbeing journey. You can also subscribe to our weekly newsletters for the latest updates at Healf and in the wellbeing industry. Subscribe via the sign-up block at the bottom of this page.
We love people who check ingredients as carefully as we do, so you'll find detailed information about the ingredients used on every product page (where applicable). If you see something you'd like to flag with us or have additional questions, please don't hesitate to get in touch—we'd love to hear from you.
New
New
Translate your body’s data
into a personalised
wellbeing plan.
Learn more
Healf Curation
Process™
Every product undergoes our rigorous Healf Curation Process, ensuring you are always getting the best when it comes to your wellbeing.
Discover more
The Discovery
Expert Validation
Community Testing