Key Benefits

• Helps reduce the look of fine lines.

• Supports firmer, smoother-looking skin.

• Lightweight serum for daily use.

Advanced Clinicals Retinol Anti-Wrinkle Serum blends retinol with squalane, green tea, and vitamin E to support smoother, firmer-looking skin. Retinol is known for helping to reduce the appearance of fine lines and uneven texture, while squalane helps maintain hydration and softness. Green tea and vitamin E provide antioxidant support, helping to protect skin from daily stressors. The lightweight, milky formula absorbs easily without leaving residue, making it suitable for daily evening use.

With continued use, Advanced Clinicals Retinol Anti-Wrinkle Serum helps skin appear visibly renewed and refreshed while supporting a smooth, comfortable feel.

Advanced Clinicals believes advanced skincare should be available to everyone, every day. Backed by over 25 years of in-house research, their formulas feature clinically proven ingredients chosen for their specific benefits. All products are dermatologist tested, cruelty-free, and made in the USA, free from parabens, sulphates, phthalates, dyes, and DEAs. From face and body care to hair care, Advanced Clinicals offers science-led skincare you can use daily to support your routine.

With our Healf Curation Process, we do the work for you. Shop with confidence knowing that every item has been tried, tested, and curated for you.

Learn more about each step—Brand Discovery, Expert Validation, and Community Testing—here.

Aqua/Water/Eau, Isopropyl Myristate, Glycerin, Ethylhexyl Olivate, Cetearyl Alcohol, Pyrus Malus (Apple) Fruit Extract, Squalane, Aloe Barbadensis Leaf Juice Powder, Propanediol, Avena Sativa (Oat) Bran Extract, Retinol, Tocopherol, Camellia Sinensis Leaf Extract, Oryza Sativa (Rice) Bran Extract, Citrus Aurantium Dulcis (Orange) Peel Extract, Helianthus Annuus (Sunflower) Extract, Humulus Lupulus (Hops) Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Helianthus Annuus (Sunflower) Seed Oil, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phenoxyethanol, Caprylyl Glycol Ethylhexylglycerin, Hexylene Glycol, Cyamopsis Tetragonoloba (Guar) Gum, Copernicia Cerifera (Carnauba) Wax, Polysorbate 20, Tetrasodium Glutamate Diacetate, 1,2-Hexanediol, Disodium Cocoamphodipropionate, Xanthan Gum, Ethyl Ferulate, Parfum/Fragrance, Limonene.

Apply a thin layer to clean face and neck at night. Follow with your favorite Advanced Clinicals face cream. Avoid using alongside Vitamin C. Use Vitamin C in the morning and Retinol at night.