Superoxide Dismutase 3 Enzyme Mist

Key Benefits

• Supports antioxidant skin defence.

• Helps preserve collagen appearance.

• Improves skin tone uniformity.

• Delivers instant hydration boost.

Superoxide Dismutase 3 Enzyme Mist (SDEM3) is a water-based antioxidant face mist formulated to support long-term skin integrity and visible skin quality. The formula focuses on protecting the skin from environmental stressors while supporting hydration, tone evenness, and the appearance of firmness.

It contains superoxide dismutase 3 (SOD3), a newly isolated form of a naturally occurring antioxidant enzyme, to help preserve the skin’s natural collagen in the presence of environmental aggressors linked to visible ageing. With added oxidised glutathione, the mist supports brighter-looking skin and helps balance uneven skin tone.

The formulation includes algin biosaccharide gum-4 to smooth the appearance of fine lines while supporting firmness. It also contains acetyl zingerone to support the skin’s natural defence systems and improve visible skin texture. With added Nicotiana benthamiana hexapeptide-40 sh-polypeptide-2, the formula supports protection against environmental stressors while promoting a more even-looking complexion.

This lightweight mist delivers an immediate hydration boost and refreshes the skin throughout the day. With a pH range of 5.0–6.0, the alcohol-free, oil-free, and silicone-free formula suits all skin types and aligns with vegan, gluten-free, and cruelty-free standards.

Superoxide Dismutase 3 Enzyme Mist responds to the daily oxidative stress caused by pollution, emissions, and environmental exposure that continually challenge skin health. The formula centres on advanced antioxidant defence, introducing four next-generation antioxidants, including SOD3, a newly isolated enzyme in skincare. SOD3 works between outer skin cells, where it can better defend against free radical damage that contributes to collagen breakdown and visible signs of ageing. By reinforcing antioxidant protection at this critical level, the mist supports skin resilience and structural strength over time.

NIOD was founded by Brandon Truaxe as an advanced skincare laboratory dedicated to pushing formulation science forward. Each product is developed using cutting-edge molecular technologies, multi-pathway delivery systems, and precisely calibrated ingredient structures designed to work at a cellular level. NIOD formulations prioritise functional concentrations, stability, and bioavailability, with every component selected for a specific, measurable role in skin health. Produced with rigorous testing and full ingredient transparency, NIOD delivers technically sophisticated skincare that allows you to support skin function with precision, confidence, and scientific integrity.

With our Healf Curation Process, we do the work for you. Shop with confidence knowing that every item has been tried, tested, and curated for you.

Learn more about each step—Brand Discovery, Expert Validation, and Community Testing—here.

Aqua/Water/Eau, Propanediol, Butylene Glycol, Superoxide Dismutase 3, Ergothioneine, Oxidized Glutathione, Acetyl Zingerone, Nicotiana Benthamiana Hexapeptide-40 SH-Polypeptide-2, Hydrolyzed Hyaluronic Acid, Ectoin, Arginine, Sorbitol, Biosaccharide Gum-4, Mirabilis Jalapa Extract, Glycerin, Gellan Gum, Algin, Maltodextrin, Sodium Phytate, Phytic Acid, Sodium Chloride, Trisodium Ethylenediamine Disuccinate, 1,2-Hexanediol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin.

Apply to the face in the morning and evening.

If irritation occurs, rinse off, cease use, and consult a physician.

Use only as directed on unbroken skin.

Patch testing prior to use is advised.

Keep out of reach of children.

Note: Layering copper peptides with other antioxidants on skin can sometimes result in them interacting with each other, leading to a colour change of the products on the skin, which can transfer to light coloured fabrics. SDEM3 can be layered with CAIS/CAIL without this issue. Mist SDEM3 onto skin, wait a minute or 2 for it to dry down, then follow with CAIS or CAIL