TMG

Trimethylglycine, better known as TMG or betaine, is a naturally occurring compound found in foods such as beetroot, spinach and quinoa. It acts as a methyl donor to support key metabolic processes, while also helping cells stay balanced and protected under stress.

TMG supplements are best known for supporting methylation, helping the body recycle homocysteine into methionine. That makes them a popular choice for cardiovascular, cellular and healthy ageing routines.

TMG also helps cells manage hydration and stress, which is why it often appears in performance supplements. Research is exploring wider roles in muscle power, endurance and healthy liver metabolism too.

Yes, TMG can raise total and LDL cholesterol, particularly at higher daily intakes. That may offset some of the benefits of lowering homocysteine.

TMG can interfere with sleep for some people, particularly when taken later in the day. Its role in methylation and energy production may leave you feeling more alert, wired or mentally switched on. Take it in the morning, ideally with breakfast, and start with a lower amount to see how you respond. Some people pair TMG with glycine supplements, a calming amino acid that may help balance its more stimulating effects.